An international team of researchers led by Dr. José Ángel Martínez-Climent at the Cima University of Navarra has created mouse avatars of patients with multiple myeloma to study and develop personalized treatments against this blood cancer.

By using genetic engineering and multi-omic cellular and molecular technologies to analyze more than 500 genetically heterogeneous mice that develop multiple myeloma and tumor cells from more than 1,000 patients with the disease, they have generated artificial mice that accurately reflect the origin and development of multiple myeloma in humans.

This will allow researchers to design more effective and personalized therapies for multiple myeloma and opens a pathway for research into other non-curable hematological and solid tumors. The research will also allow researchers to anticipate treatment outcomes with next-generation immunotherapies and mimic in the laboratory clinical situations associated with the worst outcomes. The ultimate goal is to transfer the discoveries from the laboratory to the clinic and for research initiatives such as theirs to be extrapolated to other hematological malignancies and solid tumors that remain incurable with currently available treatments.

Article written by  Technology Networks



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