MIT researchers have developed a system that can inject proteins into individual human cells using a tool found in bacteria. The system, called an «extracellular contractile injection system» (eCIS), can recognize the specific cells it is supposed to inject and deposit a protein payload using a microscopic syringe. The researchers used artificial intelligence to redesign the fibers on the eCIS to identify and bind to various human or mouse cells. The potential medical uses for the system include delivering various proteins, including those that kill cancer cells, into human cells. The system did not trigger a detectable immune response in live mice, making it a promising delivery vehicle for gene therapies.
Article written by kristin Houser