Scientists have developed a groundbreaking method to store and distribute crucial protein therapeutics without the need for refrigeration, as detailed in a recent Nature publication. This innovative approach could vastly enhance the accessibility of essential protein-based drugs in developing regions where cold storage is scarce, significantly aiding in diagnosing and treating serious health conditions.
Researchers from the Universities of Manchester, Glasgow, and Warwick designed a hydrogel that stabilizes proteins at temperatures up to 50°C, maintaining their properties and functionality. This technology is revolutionary, enabling the safe mailing of proteins without any loss in effectiveness, thus offering more cost-effective and energy-efficient ways to deliver vital treatments.
Protein therapeutics, essential for treating conditions like cancer, diabetes, and obesity, traditionally require cold storage to remain stable. The new hydrogel, made from a low molecular weight gelator (LMWG), traps proteins in a network of stiff fibers, preventing them from mixing and aggregating, which preserves their effectiveness.
Professor Dave Adams from the University of Glasgow highlighted the significance of this development, especially in overcoming the challenges of the existing cold chain logistics. The hydrogel demonstrated impressive stability during rigorous testing, including high-temperature storage and physical stress, ensuring robust delivery systems that require less careful handling.
The research showed that proteins such as insulin and beta-galactosidase retained their functionality after being stored in the hydrogel and subjected to harsh conditions. This advancement could revolutionize the pharmaceutical and diagnostic industries by facilitating the room-temperature storage and distribution of protein therapeutics, free from harmful additives.
The team is now exploring commercial opportunities for this patent-pending technology and further applications. Researchers from the University of East Anglia and Diamond Light Source Ltd also contributed to this promising research, supported by various European and UK funding bodies.
Article written by University of glasgow
17/07/2024
Source:
University of Glasgow
https://www.gla.ac.uk/news/headline_1091761_en.html