Researchers from the University of Toronto have developed a groundbreaking biodegradable electrode that can stimulate neural precursor cells (NPCs) in the brain. This flexible device delivers targeted electrical stimulation for up to seven days before naturally dissolving, offering a temporary and safe method for stimulating neural repair.
This innovative device delivers targeted electrical stimulation for up to seven days before naturally dissolving, offering a temporary yet precise solution for addressing neurological disorders.
Neurological disorders, which are among the leading causes of disability worldwide, often result in irreversible cell damage. Stimulating NPCs—rare cells that have the ability to repair neural tissue—holds promise as a potential strategy to expand treatment options for these conditions. However, current treatments such as transcranial direct current stimulation (tDCS) lack precision and can cause tissue damage. The new electrode developed by the University of Toronto team provides a safer, more controlled alternative without the need for subsequent surgical interventions.
The electrode’s material, poly(lactic-co-glycolic) acid (PLGA), is biocompatible and dissolves at predictable rates, ensuring minimal inflammation. Molybdenum was chosen for the electrode itself, providing durability and controlled degradation.
In pre-clinical trials, the electrode successfully stimulated NPCs, enhancing their activity without causing significant tissue damage. This breakthrough could mark a step forward in treating neurological disorders by offering a non-invasive, temporary solution. The team plans to further develop the technology to combine electrical stimulation with drug and gene therapies to enhance outcomes for patients with brain injuries.
Article written by Qin Dai
13/01/2025
Source:
University of Toronto