Atomic force microscopy (AFM) has made a significant leap in molecular medicine by providing a completely new way to «feel» cells and better understand diseases. Combining this technique with artificial intelligence (AI), scientists at the Institute of Materials Science of Madrid (ICMM-CSIC) have developed innovative methods that allow for the study of the mechanical properties of cells, such as their viscoelasticity and rheology, key aspects in understanding how cells function and respond to mechanical stimuli.
AFM uses an extremely fine tip to interact with cells, effectively «drawing» their shape at a molecular level, much like a finger reading braille. This precision has been crucial in advancing our understanding of diseases such as certain types of cancer and cardiovascular conditions. One of the latest findings, published in Nature, revealed how neutrophils, immune cells, not only fight infections but also help in wound healing by altering the mechanical properties of tissues.
Additionally, the use of machine learning has sped up the process of data interpretation, making it faster and more accurate. These advancements not only offer new insights into how cells respond to mechanical stimuli but also open new doors for treating diseases, from cancer to cardiovascular issues.
With these breakthroughs, Ricardo García’s team has made a crucial step forward in improving our understanding of how cells react to mechanical factors, providing more precise tools for diagnosing and treating diseases.
Article written by Ángela R. Bonachera / ICMM – CSIC
21/04/2025
Source:
Salud a Diario